Signatures are computed after DESeq2 pre-filtering (~13,660 genes, |log2FC|>1.5, BH p<0.05) and pseudogene removal.
Rank Gene Importance Score
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⚠️ Pseudogenes are automatically filtered. If a top-10 gene is flagged as pseudogene, it is removed and scores renormalised.

πŸ†• v2 β€” Weighted consensus ranking + stability selection

The legacy union of top-N is replaced by a rank-space consensus (LR 0.3 / RF 0.3 / MLP 0.4) with 4-of-5-fold stability filtering. See the consensus table per cohort β†’