Key Findings
Per-cancer research narrative β from ML classification to evolutionary candidate identification.
π Overview
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π¬ Gene Filtering Pipeline
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π§¬
Top Candidates
β
| Gene | Germline dN/dS | Somatic dN/dS | FDR | Non-syn Muts |
|---|---|---|---|---|
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π Evolutionary Landscape
Germline vs Somatic dN/dS
βοΈ Cross-Cancer Validated Genes
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| Gene | # Cancers | Cancer Types |
|---|---|---|
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Updated Thresholds (April 2026):
Somatic dN/dS raised from >1.0 to β₯1.5 with CI lower bound >1.0 required.
This reduces false positives from neutral drift.
Germline dN/dS threshold remains <0.3 for purifying selection.